Uveitis
Uveitis is inflammation of the uvea, the middle layer of the eye that consists of the iris, ciliary body, and choroid. It can affect one or both eyes and can lead to serious complications, including vision loss if not treated promptly.
Experimental Auto-Immune Uveitis
Experimental Autoimmune Uveitis (EAU) is a well-established, consistent animal model in rodents, rabbits, and pigs used to study the mechanisms of autoimmune uveitis, a form of intraocular inflammation that affects the uvea.
Endotoxin-Induced Uveitis
Endotoxin-Induced Uveitis (EIU) is an experimental model used to study acute anterior uveitis and the inflammatory response in the eye. This model is primarily induced iN rodents and rabbits, by administering endotoxins, particularly lipopolysaccharides (LPS).
TNF-Induced Uveitis
TNF-Induced Uveitis (TIU) is an experimental model used to study the role of tumor necrosis factor-alpha (TNF-α) in the pathogenesis of uveitis, particularly anterior uveitis. TNF-α is a pro-inflammatory cytokine produced by various immune cells, including macrophages and T cells, and plays a central role in the inflammatory response seen in autoimmune and infectious uveitis in humans. Our team of experts has developed reproducible models with consistent results in rodents.
Mycobacterium Tuberculosis-Induced Uveitis
Mycobacterium tuberculosis-induced uveitis refers to uveitis caused by infection with Mycobacterium tuberculosis, the bacterium responsible for tuberculosis (TB). TB uveitis can manifest in various forms depending on the location and severity of the infection within the eye. Our team of experts has developed reproducible models with consistent results in rodents.