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Safety, Tolerability, & Toxicology

Whether you’re developing a new chemical entity, a new formulation of a marketed product, or a new drug delivery system, obtaining an understanding of any potential adverse effects is critical before moving into definitive GLP studies. Powered Research has developed internal protocols for non-GLP assessment of ocular therapeutics, providing key tolerability and safety data.


Our ocular tolerability studies are conducted in rodents, rabbits and swine with various route of administration, and include standard toxicology endpoints. Additionally, all ophthalmic exams are conducted by a Board-Certified Veterinary Ophthalmologist, lending significant credibility to the results obtained.

Endpoints Include:

  • Clinical Observations: cageside and detailed observations

  • Physiological Measurements: Body weight, food consumption

    • Slit lamp biomicroscopy with SPOTS or Hackett-McDonald scoring 

    • Indirect ophthalmoscopy conducted by a Board-Certified Veterinary Ophthalmologist

    • High-resolution imaging

    • Tonometry, Pupillometry, Pachymetry

    • Electrophysiology (ERG, OKT)

    • Fluorescein angiography

    • Optical coherence tomography

  • Pharmacokinetics: Systemic (plasma, serum)

  • Pathology: Necropsy with macroscopic observations, ocular histopathology

  • Immunohistochemisty/Immunofluorescence

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At Powered Research with a collaborative mindset and deep technical expertise, we seamlessly impact our Sponsors’ research and development pipelines, transforming discoveries into validated product candidates. Guided by integrity, excellence, and a commitment to making a meaningful impact, we strive to advance scientific progress and deliver real-world solutions. 

 

Please contact us at info@poweredresearch.com to learn how we can help grow your company.​​

Powered Research is proudly located in Research Triangle Park, NC

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984-884-4928

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