Oncology

We offer a full suite of services for evaluating potential cancer therapeutics from
experimental design and in vivo tumor modeling to extensive endpoint analyses. Our
team is fully equipped to ensure start-to-finish characterization of your test agent on
an expedited timeline.

Our Expert Leadership Team shares decades of drug development experience
Dr. David Culp, Senior Vice President; Kay Meshaw, Sr. Study Director; Beth Hollister, Director of Operations

Our Capabilities:

Rodent housing in a 20,000 sq ft
multi-species vivarium staffed by
highly trained technicians and
veterinarians
Human and murine cell culture in a
modern 2000 sq ft laboratory
Flexible and customized flow
panels for deep immune profiling
with our 5-laser Cytek® Aurora
spectral cytometer

All-in-one Service:

Study design
Cell culture and implant
Test agent dosing via any route
Timed samplings and necropsy

Endpoint Data:

Tumor volume and Body Weight
MTDs and Dose Range Finding
PK/PD
Immunophenotyping by flow cytometry
Cytokine analysis
H&E staining
Immunohistochemistry
Immunofluorescence
Image analysis

FULL SPECTRUM FLOW CYTOMETRY:

5-laser Cytek® Aurora flow
cytometer with automated sample
loader
Expansion beyond 18 color panels
and improved resolution of
subpopulations
Autofluorescence extraction
Pre-optimized and custom panel
options available
Panel qualification

TISSUE SECTIONING AND
IMAGING:

Start to Finish tissue processing:
- Cell/organ/tumor collection and
  fixation
- Paraffin embedding and
  cryopreservation
- Sectioning and staining
- Epifluorescence microscopy
Histological stains & antibodies for
diagnostic & marker-based analysis:
- Hematoxylin & eosin
- Immune cell markers including but
  not limited to: CD3, F4/80, CD4,
  CD8, CD68
- Endothelial markers: CD31 &
  Isolectin I-B4
- Many More!

OTHER IN-HOUSE SERVICES
INCLUDE:

qPCR
ELISA
Western Blot
Immunohistochemistry
In situ hybridization