Toxicology (TK)

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Toxicology (TK)

Whether you’re developing a new chemical entity, a new formulation of a marketed product, or a new drug delivery system, obtaining an understanding of any potential adverse effects is critical before moving into definitive GLP studies. Powered Research has developed internal protocols for non-GLP assessment of ocular therapeutics, providing key tolerability and safety data.
Our ocular tolerability studies are conducted in rodents, rabbits, swine, or canine with various route of administration, and include standard toxicology endpoints. Additionally, all ophthalmic exams are conducted by a board-certified veterinary ophthalmologist, lending significant credibility to the results obtained.
Endpoints include:

ICageside and detailed clinical observations


IBody weight, food consumption


ISlit lamp Biomicroscopy with Hackett-McDonald scoring and indirect ophthalmoscopy conducted by a Board-certified veterinary ophthalmologist


IHigh-Resolution Imaging


ITonometry, Pupillometry, Pachymetry


IElectrophysiology (ERGs, VEPs)


IFluorescein Angiography


IOptical Coherence Tomography


ISystemic Pharmacokinetics (plasma, serum)


INecropsy with macroscopic observations


IOcular histopathology

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